The Alex Madonna Expo Center is located at 100 Madonna Road in San Luis Obispo, CA. San Luis Obispo is located 232 miles south of San Francisco and 190 miles North of Los Angeles. Take 101 towards San Luis Obispo and exit at Madonna Rd. Head west on Madonna Rd. and you will see the entrance to the Madonna Inn Resort. A trolly will be provided to take you from the parking lot up to the entrance of the show.